Added Allergenicity explanation to "Browse the Database" table on 10 May 2018 based on historical reviews:
Version 18B on 23 March 2018: History of the AllergenOnline database releases
The table below shows the total count of sequences in each release of the allergen online database.
Also shown are the number of allergen groups (A collection of protein types within a taxonomic group)
and number of unique species represented in each version.
Note, version 18 update was released on 18 January 2018, but was missing some information of WHO/IUIS allergen numbers and also used a few accession numbers that were not optimum. A full review of the database was performed from 19 January until 31 January with corrections made as version 18A which was posted on 1 February 2018.
NOTE 2: Removal of green-fluorescent protein from Scleronephthya gracillima on 23 March 2018.
In March, 2018 we were asked an important question regarding the validity of the allergenicity of the green-fluorescent protein from Scleonephthya gracillima an octocoral coral. There are four proteins of greater than 90% identity and only one paper, from Kato et al., 2017, Luminescence 32(6):1009-1016. Our panel had given it mixed reviews in accepting that as a putative allergen. Upon re-review 20 March, 2018, the full panel agreed the data from Kato et al., did not demonstrate specificity of IgE binding. Their patient population was unspecificied lobster fishermen from Japan with dermatitis or asthma. Pooled sera was used to demonstrate IgE binding. There was markedly more binding to two other uncharacterized proteins, altough the major IgE binding protein also had binding from a pool of "non-allergic" subjects. The protein sequence was determined by a peptide from LC-MSMS, then cDNA clones were constructed. The allergic subjects sera was not used to demonstrate IgE binding to pure protein. We conclude that the IgE binding was not specific or that the binding was sufficiently weak and the protein should not be included even as a "putative" allergen, our lowest category of allergen. A more detailed report can be obtained by email request to rgoodman2@unl.edu.
Letter GFP removal
| Version | Release Date | Sequences | Groups | Species |
|---|---|---|---|---|
| 5 | Jan 2005 | 1189 | 608 | 208 |
| 6 | Jan 2006 | 1537 | 672 | 255 |
| 7 | Jan 2007 | 1251 | 461 | 221 |
| 8 | Jan 2008 | 1313 | 483 | 229 |
| 9 | Jan 2009 | 1386 | 502 | 236 |
| 10 | Jan 2010 | 1471 | 529 | 254 |
| 11 | Feb 2011 | 1491 | 553 | 265 |
| 12 | Feb 7, 2012 | 1603 | 603 | 273 |
| 13 | Feb 12, 2013 | 1630 | 612 | 275 |
| 14 | Jan 20, 2014 | 1706 | 645 | 290 |
| 15 | Jan 12, 2015 | 1897 | 744 | 335 |
| 16 | Jan 27, 2016 | 1956 | 778 | 345 |
| 17 | Jan 16, 2017 | 2035 | 808 | 354 |
| 18 | Jan 18, 2018 | 2101 | 833 | 376 |
| 18A | Feb 1, 2018 | 2093 | 832 | 370 |
| 18B | Mar 23, 2018 | 2089 | 831 | 369 |
Version History of the Celiac Disease database release version 2, 18 January 2018
Version 1 of the Celiac Database was available for public use on 14 February, 2012.
A Beta version of the Celiac database was installed in August, 2017. The updates included new 9 amino acid peptide entries from the European Food Safety Authority panel as they should be bound by HLA DQ2 (DQ2.5, DQ2.2, Cis or trans) or DQ8. Beta version 2 was updated in September, 2017 with removal of 8 amino acid matches, bringing the total to 2013 peptides including native and specifically deamidated peptides. BLASTP testing with the 9 AA peptides demonstrated that a few match proteins outside of the grass family and the word "CAUTION" was added for those entries. Beta version 3 was posted on 5 October 2017 and includes four new representative proteins. The FASTA search feature has been validated again and the final Celiac Disease database version 2 release was 18 January 2018. RE Goodman
