Added Allergenicity* to explain differences in "proof" of allergenicity as either "IgE binding but no biological test" or "IgE binding plus basophil+ or SPT+" results within the "Browse the Database" table
Note on removal of the entry of "Green Fluorescent protein", Schleronephytha gracillima in Version 18B on 23 March 2018: The only publication did not provide meaning demonstration of allergic reactivity or reproducible IgE binding for this protein. It is from a coral that grows on lobsters and may be associated with IgE binding in a few Japanese lobster fishermen in the Sea of Japan. That protein remains out in Version 19. In March, 2018 we were asked an important question regarding the validity of the allergenicity of the green-fluorescent protein from Scleonephthya gracillima an octocoral coral. There are four proteins of greater than 90% identity and only one paper, from Kato et al., 2017, Luminescence 32(6):1009-1016. Please see the Letter GFP removal.pdf for an explanation. Please email Richard Goodman at rgoodman2@unl.edu with any questions.
Letter GFP removal
| Version | Release Date | Sequences | Groups | Species |
|---|---|---|---|---|
| 5 | Jan 2005 | 1189 | 608 | 208 |
| 6 | Jan 2006 | 1537 | 672 | 255 |
| 7 | Jan 2007 | 1251 | 461 | 221 |
| 8 | Jan 2008 | 1313 | 483 | 229 |
| 9 | Jan 2009 | 1386 | 502 | 236 |
| 10 | Jan 2010 | 1471 | 529 | 254 |
| 11 | Feb 2011 | 1491 | 553 | 265 |
| 12 | Feb 7, 2012 | 1603 | 603 | 273 |
| 13 | Feb 12, 2013 | 1630 | 612 | 275 |
| 14 | Jan 20, 2014 | 1706 | 645 | 290 |
| 15 | Jan 12, 2015 | 1897 | 744 | 335 |
| 16 | Jan 27, 2016 | 1956 | 778 | 345 |
| 17 | Jan 16, 2017 | 2035 | 808 | 354 |
| 18 | Jan 18, 2018 | 2101 | 833 | 376 |
| 18A | Feb 1, 2018 | 2093 | 832 | 370 |
| 18B | Mar 23, 2018 | 2089 | 831 | 369 |
| 19 | Feb 10, 2019 | 2129 | 853 | 384 |
Version History of the Celiac Disease database release version 2, 18 January 2018.
The updates included new 9 amino acid peptide entries from the European Food Safety Authority panel as they should be bound by HLA DQ2 (DQ2.5, DQ2.2, Cis or trans) or DQ8. Beta version 2 was updated in September, 2017 with removal of 8 amino acid matches, bringing the total to 2013 peptides including native and specifically deamidated peptides. BLASTP testing with the 9 AA peptides demonstrated that a few match proteins outside of the grass family and the word "CAUTION" was added for those entries. Beta version 3 was posted on 5 October 2017 and includes four new representative proteins. The FASTA search feature has been validated again and the final Celiac Disease database version 2 release was 18 January 2018. RE Goodman
Version 1 of the Celiac Database was available for public use on 14 February, 2012.
